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There was no heterogeneity in these six included studies in their assessment of the effect of GLP-1 receptor agonists on the risk of death from cardiovascular causes and fatal or non-fatal stroke

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This accidental discovery redirected tesofensine development entirely toward obesity treatment , where it demonstrated 10-12% body weight reduction in 24-week trials - rivaling results from semaglutide and tirzepatide but through a completely different mechanism